Priceline.com Inc. (Nasdaq: PCLN) shares were up 7.1% to $456.11, on share volume of 2.9 million shares, or three times its average, a day after the online travel-booking service said its fourth-quarter net income rose 73%.

Cisco Systems Inc. (Nasdaq: CSCO) was among volume leaders Thursday, particularly among tech stocks, by trading in 30.6 million shares, nearly half its all-day average of 71.9 million. Prices for CSCO were flat at $18.39

Salix Pharmaceuticals Inc. (Nasdaq: SLXP) stumbled in price to 22.8% to $32.01 Thursday, on share volume of 8.9 million, more than 10 times its daily average, after the Raleigh company said that the FDA wasn’t ready to approve one of its drug candidates without more information.