NPS Pharmaceuticals Inc. (Nasdaq: NPSP) shares climbed 28.9 percent to $9.91, on volume of 4.1 million shares, or more than eight times its daily average, after it said a study yielded positive results on its drug candidate for a rare bowel condition.

Ford Motor Company (NYSE: F) was a volume leader Monday, trading in 61.3 million shares, rapidly catching up on a daily volume of 87.7 million. Prices, however, dipped one percent to $16.10, after Credit Suisse trimmed its price target by following the company’s 4Q10 earnings miss.

Alpha Natural Resources Inc. (NYSE: ANR) shares were off 7.3% to $53.70 on news over the weekend that it will acquire coal producer Massey Energy Co. (NYSE: MEE). Volume for ANR was 18.2 million shares, more than six times normal.