GTX Inc. (Nasdaq: GTXI) shares advanced 41.8% to $3.90, on volume of 2.9 million, dwarfing an average of only 85,000, after Citigroup Inc. upgraded the drug company to buy from hold.

Cisco Systems Inc. (Nasdaq: CSCO) traded in 49.2 million shares, making it a volume leader Wednesday, but still falling below its average of 77.5 million. Share prices were down 1.2% to $17.24.

China North East Petroleum (AMEX: NEP) plummeted 15.9% to $3.22, on volume of 2.5 million, towering over a daily average around 440,000.