Marshsall Edwards Inc. (Nasdaq: MSHL) shares spiked 21.8 percent to $2.63, on volume of 114,403 shares, tripling its daily average.

Cisco Systems Inc. (Nasdaq: CSCO) was among the volume leaders Wednesday, trading in 46.2 million shares compared to a daily average of 72.8 million. Share prices shaved off 0.6 percent to $21.41.

Good Times Restaurants Inc. (Nasdaq: GTIMD) shares jettisoned 34.3 percent to $3.11 Wednesday, on volume of 186,771 shares, compared to a daily average of 5,000. The Colorado-based restaurant chain said December was its fifth consecutive month of same-store sales increases. It said that same-store sales were up 13.4 percent in the just-completed first quarter of fiscal 2011 from a year earlier.