Granite City Food & Brewery Ltd (Nasdaq: GCFB) climbed 28.8 percent in price Wednesday to $5.15. Volume of 435,825 shares proved more than 30 times its all-day average. GCFB is a Modern American, upscale casual restaurant chain that operates 26 restaurants in 11 states.

Atheros Communications Inc. (Nasdaq: ATHR) was busy Wednesday, trading in 59,373,397 shares, dwarfing its daily average of 2,139,870. Prices for the stock gained 1.1 percent to $44.50. The firm is under investigation related to the proposed buyout of Atheros by Qualcomm.

Adeona Pharmaceuticals Inc. (AMEX: AEN) dropped 17.3 percent Wednesday to $1.53, on volume of 1,034,404 shares, more than four times its full-day average. AEN is a developer of innovative medicines for serious central nervous system diseases, based out of Ann Arbor, Michigan.