Affymetrix Inc. (Nasdaq: AFFX) shares gained 16.4% to $5.46 Wednesday. Volume of 1,666,321 proved nearly double its full-day average. The rise comes after the company said it expects to report a profit in the fourth quarter and announced that it signed a distribution deal with Thermo Fisher Scientific.

Sprint Nextel Corporation (NYSE: S) traded in 39,482,210 shares Wednesday, approaching its daily average of 45,195,800. Prices for S nudged ahead 0.3 percent to $4.41.

SuperMedia Inc. (Nasdaq: SPMD) fell 7.2 percent Wednesday to $8.82 Volume for the stock was 443,787 shares, surpassing its daily average of 396,158. SPMD is an advertising agency for local small- to medium-sized businesses across the United States.