Archive for June, 2009

Buzz Stock of the Day – Antigenics (AGEN)

Wednesday, June 3rd, 2009

Our Buzz Stock of the Day — Antigenics, Inc. (Nasdaq: AGEN) — was the big winner of today’s bio-tech rally.

Earlier this week, Antigenics said an analysis of patient data showed that patients with kidney cancer at intermediate risk of disease recurrence demonstrated an approximately 46 percent lower risk of death when treated with the company’s Oncophage® (vitespen) cancer therapy. Oncophage is currently approved only in Russia. The company has also filed for approval in the European Union.
Shares of Antigenics have risen almost 250% over the last 30 days.

“Demonstration of an overall survival benefit remains the gold standard, and these interim results show that Oncophage has a real promise of improving survival in patients with earlier-stage disease for whom current prognosis remains poor,” said Dr. Christopher Wood, who presented the survival results at the annual meeting of the American Society of Clinical Oncology. “Based on these results, Oncophage offers these patients a potential treatment that extends survival without significant toxicities.”

Buzz Stocks of the Day – Aeterna Zentaris (AEZS), Keryx Biopharmaceuticals (KERX)

Monday, June 1st, 2009


Shares of Canadian biotech firm, Aeterna Zentaris, Inc. (Nasdaq: AEZS) were up as much as 35 percent in mid day trading today after its partner, Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) announced positive Phase 2 data from its cancer treatment perifosine (KRX-0401), an Akt-inhibitor compound that is used as a treatment for colon and kidney cancer.

Perifosene is in-licensed by Keryx from Aeterna Zentaris.

The data was presented over the weekend at the American Society of Clinical Oncology Annual Meeting. The poster #4081 entitled, “Randomized Phase 2 study of perifosine in combination with capecitabine versus capecitabine alone in patients with second- or third-line metastatic colon cancer”, showed that perifosine combined with capecitabine, more than doubled time to progression versus capecitabine plus placebo with a statistically significant p-value. In addition, perifosine plus capecitabine more than doubled the Overall Response Rate and almost doubled the Clinical Benefit Rate versus capecitabine plus placebo.

Aeterna Zentaris’ annual revenues during the last years have been in the range of $35 million to $40 million, coming from sales of marketed products, license agreements and services.

In March 2009, the company signed a collaboration agreement with leading pharmaceutical company, Sanofi-Aventis (NYSE: SNY) for the commercialization of the company’s lead compound, cetrorelix, which is used in treating benign prostatic hyperplasia (BPH), a benign enlargement of the prostate.

“The agreement provided us with an upfront payment of $30 million, bringing the total of our non-dilutive funding over the last 18 months to roughly $100 million,” said Aeterna Zentaris CEO, Juergen Engel Ph.D, in a recent interview.

Join the discussion on our Buzz Stocks Board, and find out what other investors think about AEZS.