Archive for the ‘Health Care Stocks’ Category

Trubion Pharmaceuticals, Inc. (TRBN) – Buzz Stock of the Day

Friday, August 28th, 2009

Shares of Trubion Pharmaceuticals, Inc.(NASDAQ: TRBN) were up as much as 76 percent in morning trading on Friday, after the company announced a drug development deal for its leukemia drug with Facet Biotech Corp.(NASDAQ: FACT) .

“In considering alliance opportunities for TRU-016 we sought to retain meaningful economics in this exciting first-in-class product candidate, while enabling aggressive joint development with a partner who shared our vision and brought complementary experience and resources to the alliance,” said Trubion’s Chairman and CEO, Dr. Peter Thompson.

Trubion will receive $20 million upfront from Facet, with the potential for an additional $176.5 million based on certain developmental, regulatory and commercialization milestones. Additionally, Facet will purchase 2.2 million newly-issued shares of Trubion common stock, worth approximately $10 million.

TRU-016 is currently in clinical development for the treatment of B-cell malignancies, otherwise known as chronic lymphocytic leukemia (CLL, and is a CD37-directed Small Modular ImmunoPharmaceutical (SMIP™) protein therapeutic. TRU-016 uses a different active mechanism than CD20-directed treatments, and as a result, may provide cancer patients enhanced therapeutic options and improved effectiveness when used alone or with chemotherapy and/or CD20-based therapeutics. The drug could also have the potential to treat other cancers that affect the immune system’s B-cells, along with autoimmune and inflammatory diseases.

In June 2009, positive results following preliminary analysis from the Phase 1 clinical trial of TRU-016 for the treatment of CLL were announced. The objectives of the Phase 1 TRU-016 CLL study were to define safety and tolerability, identify a maximum tolerated dose, evaluate pharmacology and pharmacodynamics, and assess preliminary clinical activity.

“(The Trubion drug) is a promising therapeutic with impressive preclinical and preliminary clinical data for CLL that will greatly enhance our pipeline and support a key strategic objective, which is to build a robust oncology portfolio,” said Faheem Hasnain, president and CEO of Facet Biotech, in a statement.
Both companies will share costs associated with developing, selling and marketing the drug. The deal also states that Facet and Trubion will share worldwide rights to the drug as well as rights to other, similar CD37-directed protein therapeutic drugs in Trubion’s pipeline.

“We are delighted to have Facet as our partner,” Dr. Thompson said. “Coupled with our own strengths in the discovery and development of novel protein therapeutics, their expertise will afford us the opportunity to pursue the clinical development and commercialization of TRU-016 and other CD37-directed therapeutics in the most aggressive manner possible.”

TorreyPines Therapeutics, Inc. (TPTX) Buzz Stock of the Day

Wednesday, August 26th, 2009

Shares of TorreyPines Therapeutics, Inc.(NASDAQ: TPTX) skyrocketed more than 261 percent in morning trading after proposed merger candidate, Raptor Pharmaceuticals, Inc. (OTCBB: RPTP) announced it raised $5 million through a private placement offering. A portion of the proceeds would be used to close a merger with TorreyPines, which was announced in late July.

Raptor raised $2.6 million in a private placement and another $2.4 million in a warrant exchange. The company sold 7.5 million units (each a share of stock and a warrant to buy another half share). It also raised about $2.4 million by exchanging warrants from a previous private placement in 2008 for new warrants. Proceeds will also be used to fund late-stage drug development and commercialization.

Under terms of the agreement, Raptor will be merged with and into a wholly owned subsidiary of TorreyPines, and TorreyPines will issue its common stock to Raptor stockholders. TorreyPines stockholders will own about 5 percent in the combined company, which will be named Raptor Pharmaceuticals, the companies said. The merger is expected to complete in the fourth quarter of 2009, dependent on the review process by regulatory agencies.

Additionally, TorreyPines will implement a reverse stock split to ensure compliance with Nasdaq listing requirements, and the size of the split will be determined at closing.

Raptor CEO, Christopher Starr will be the CEO of the combined company. TorreyPines CEO Evelyn Graham, CFO Craig Johnson, and Vice President Paul Schneider will remain with the combined company under new employment contracts that expire in 2010. TorreyPines directors have agreed to quit when the deal is closed.

TorreyPines’ products under development include Tezampanel, which completed Phase II clinical trial for the treatment of migraine; and NGX426, which completed Phase I clinical trial for the treatment of migraine and neuropathic pain. It also develops NGX267, a Phase II clinical trial product for the treatment of Xerostomia; and a Gamma-secretase modulator drug discovery program as a treatment for Alzheimer s disease. The company has a strategic alliance and licensing agreements with Eisai Co., Ltd.; Eli Lilly and Company; Life Science Research Israel, Ltd.; and University of Iowa Research Foundation.

Anika Therapeutics Inc. (ANIK) Buzz Stock of the Day

Wednesday, August 19th, 2009

Shares of Anika Therapeutics, Inc. (NASDAQ: ANIK) rose nearly 74 percent on Thursday after the drug maker received approval from Health Canada for its osteoarthritis of the knee treatment, MONOVISC™. The product will be distributed in Canada by Anika’s distribution partner, Helix BioPharma Corp.

“Health Canada approval marks an important next step as we continue to expand the geographic reach of our novel osteoarthritis treatment therapy and establish MONOVISC as the premier single-injection product on the market worldwide,” said Charles H. Sherwood, Ph.D., Anika’s President and Chief Executive Officer in a statement.

The single injection viscosupplement drug has been available in the European Union since early 2008 and is currently being evaluated by the U.S. Food and Drug Administration.

The company has steadily made progress toward U.S. approval of the knee drug, and is expected to submit additional clinical data to the FDA before the end of the year. The company filed a modular premarket approval (PMA) application with the FDA for MONOVISC, which allows for submission of clinical data on an ongoing basis rather than all at once. Anika had previously presented an initial module of trial data for MONOVISC™.

MONOVISC™ is currently undergoing a retreatment study, which focuses on the safety of the drug and the benefits of repeat injections.

Anika also received a boost on Thursday as news broke that a U.S. advisory panel recommended that regulators reject a similar injection treatment for knee pain submitted by rival companies Q-Med AB and Smith & Nephew.

The panel decision could have long-term advantages for Anika if MONOVISC™ gets FDA approval. The drug would be the second single injection product on the market with the other being Genzyme Corporation’s drug, Synvisc-One™.

Oculus Innovative Sciences (OCLS)—Buzz Stock of the Day

Tuesday, August 18th, 2009

Shares of Oculus Innovatie Sciences (NASDAQ: OCLS) were up as much as 21 percent from the previous day’s closing price on Tuesday after the company announced the commercial launch of its wound care product in the United States.

The Petaluma-based company’s Microcyn® wound care gel, which received FDA 510(k) clearance in May of this year, has demonstrated rapid activity against a broad spectrum of infections and has also demonstrated wound healing in chronic and acute wounds in clinical investigational studies. It has been commercialized outside of the United States for the treatment of infected wounds.

“We’re excited to make these products commercially available so quickly after receiving our FDA clearance in May,” said Oculus founder and CEO, Hoji Alimi in a statement. “As well, we are also sampling our new Microcyn hydrogel formulations to U.S. physicians and are preparing to initiate a study of this proprietary hydrogel against other wound gels. We believe this data will provide the evidence necessary for a successful hard launch of the product into the medical community in early 2010.”

The onslaught of the swine flu epidemic in Mexico bolstered first quarter unit sales of the company’s 240-milliliter bottles of the Microcyn hydrogel, which was sold mostly to pharmacies in Mexico.

First quarter unit sales increased 100 percent over the prior year to a monthly average of 57,000 units, up from 35,000 in the fourth quarter of fiscal 2009, and 28,000 in the same quarter last year. Unit sales to hospitals increased 101 percent, partially offset by lower selling prices. Normal unit sales of the 240 mL bottles in the first quarter represent about 38,000 to 40,000 units per month, while the units over that reflect one-time purchases related to the swine flu concerns during the quarter.

Oculus cut its first quarter net loss to $3.5 million, or $0.18 per share, from a net loss of $5.2 million, or $0.33 per share reported in the same period last year. Total revenue for the quarter was $1.8 million, up 52 percent from $1.2 million last year. A 56 percent increase in product revenue, a 37 percent increase in service revenue, and a 40 percent reduction in operating expenses were a few highlights of the quarter over the same period last year.

“In our last earnings call, we provided guidance regarding two objectives to achieve cash breakeven by March 2010 and to achieve annual revenue of $45-to-$60 million by fiscal year 2013 with operating profitability of 20 percent,” said Alimi. “We are reconfirming these targets.”

Oculus is currently sampling the new professional Microcyn Skin & Wound HydroGel formulation to U.S. medical professionals. The OTC version of the HydroGel product will be available to consumers beginning October 2009.

Oculus Innovative Sciences, Inc. was first featured as a Buzz Stock of the Day in late May, when the company received marketing clearance from the FDA for Microcyn. Shares spiked from $1.80 to $4.49 that day..

Advocat, Inc. (AVCA) – Buzz Stock of the Day

Thursday, August 13th, 2009

Shares of healthcare facilities operator, Advocat, Inc.(NASDAQ: AVCA) surged nearly 17 percent in morning trading Thursday, after the company released second quarter earnings that beat analysts’ estimates.

The Tennessee-based company reported earnings of $937,000, or $0.15 per share, compared to $709,000, or $0.11 per-share for the same period a year ago. Revenue increased 7.3 percent to $76.1 million compared to a year ago.

Analysts had expected per share earnings of $0.14.

Highlights from the quarter included an increase of more than 75 percent in funds provided by operations, from $2.7 million in 2008 to $4.8 million in the second quarter of 2009. Facility also occupancy increased to 76.6 percent, from 74.7 percent in the same quarter last Advocat’s board also approved the payment of a $0.05 per share dividend commencing with the quarter ended June 30, 2009.

“We continue to record excellent comparable and sequential quarterly results in a difficult economy,” said Chief Executive Officer, William Council. “One of our most important measurements is funds provided from operations which were $4.8 million, a 75 percent increase over the 2008 comparable quarter.”

Seven of the company’s long-term nursing facilities recently received national recognition at the 2009 National Quality Awards by the American Healthcare Association (AHCA). AHCA looks at facilities that demonstrate at least a three-year track record of quality care, staff and residents’ satisfaction, and regulatory compliance.
With these awards, 37 of our 50 facilities have won National Quality Awards, with three winning Step II awards,” said Council. “We are very proud of the employees of these facilities for their commitment to quality performance.”

Advocat provides long term care services to patients in 50 skilled nursing centers, primarily in the Southeast and Southwest. It offers various non-institutional and institutional services, which include skilled nursing, ancillary health care services, and assisted living to the elderly, as well as rehabilitative, nutritional, respiratory, and other specialized ancillary services.